In which direction will the actin binding protein move? Assume that profilin, cofilin and thymosin are present but not filament capping proteins.

Answer :

In this case the motor activity of myosin moves its head groups along the actin filament in the direction of the plus end.

What is actin binding?

In eukaryotic cells, actin performs a key role as a necessary part of the cytoskeleton. The actin cytoskeleton plays a role in cell movement, cell division, endocytosis, intracellular trafficking, and the creation and maintenance of cell shape and polarity. Numerous actin-binding proteins (ABPs) control the formation and disassembly of actin filaments as well as how they are organized into useful higher-order networks in cells (dos Remedios et al., 2003; Maciver, 2004). Specific signaling pathways in turn regulate the activity of these proteins.

In this article, we outline the main classes of ABP identified in eukaryotic cells and, to the extent possible, suggest their likely mode of action based on both in vitro and in vivo research.

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