Answer :
BCR-ABL oncogene is least likely to drive cetuximab resistant colo-rectal cancer cells or other cancers driven by oncogenic egfrs that can be successfully treated by blocking antibodies such as herceptin or rtk inhibitors such as erlotinib.
Changes in key regulatory genes that regulate cell proliferation, differentiation, and survival cause cancer. Studies on tumor viruses demonstrated that some genes (referred to as oncogenes) have the ability to cause cell transformation, offering the first understandings into the molecular foundation of cancer. However, the vast majority (almost 80%) of cancers in humans don't appear to be brought on by viruses but rather by other factors like radiation and chemical carcinogens.
Therefore, it has been crucial for our entire understanding of cancer because research into viral oncogenes also resulted in the discovery of cellular oncogenes, which are responsible for the emergence of cancers that are not caused by viruses. Studies of the highly carcinogenic retroviruses provided the crucial link between viral and cellular oncogenes.
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